Developments in mucosal influenza virus vaccines
Identifieur interne : 001E41 ( Main/Exploration ); précédent : 001E40; suivant : 001E42Developments in mucosal influenza virus vaccines
Auteurs : Harumi Kuno-Sakai [Japon] ; Mikio Kimura [Japon] ; Kazuyo Ohta [Japon] ; Rumi Shimojima [Japon] ; Yasumasa Oh [Japon] ; Hideo Fukumi [Japon]Source :
- Vaccine [ 0264-410X ] ; 1994.
English descriptors
- KwdEn :
- Teeft :
- Antibody levels, Antibody responses, Booster, Challenge test, Greater increases, Immune, Influenza, Influenza vaccine, Influenza vaccines, Influenza virus, Influenza virus vaccine, Influenza virus vaccines, Influenza viruses, Intranasally, Mucosal, Mucosal influenza virus vaccines, Mucosal surfaces, Nasal, Osaka university, Preimmunization, Preimmunization serum, Research foundation, Systemic, Vaccine, Vaccine development, Vaccine virus, Virus.
Abstract
Immunogenicity and efficacy of aerosol inactivated split influenza virus vaccines, which are threefold the strength of the vaccines for parenteral use, and cold-adapted reassortant live influenza virus vaccines were evaluated. Mucosal immune responses were evaluated by quantifying specific IgA antibody of the nasal swab solution, and systemic immune responses were evaluated by determining serum haemagglutination inhibition antibody levels. Efficacy of the aerosol inactivated vaccine was evaluated by a challenge test using live vaccine virus. It was concluded that mucosally administered inactivated influenza virus vaccine stimulated systemic and mucosal immune responses more strongly than live influenza virus vaccine and manifested a much stronger booster effect than live vaccine. Mucosal administration of inactivated influenza virus vaccine was effective in preventing infection by live vaccine virus.
Url:
DOI: 10.1016/S0264-410X(94)80056-6
Affiliations:
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Mucosal administration of inactivated influenza virus vaccine was effective in preventing infection by live vaccine virus.</div></front></TEI><affiliations><list><country><li>Japon</li></country><region><li>Région de Kantō</li></region><settlement><li>Tokyo</li></settlement></list><tree><country name="Japon"><noRegion><name sortKey="Kuno Sakai, Harumi" sort="Kuno Sakai, Harumi" uniqKey="Kuno Sakai H" first="Harumi" last="Kuno-Sakai">Harumi Kuno-Sakai</name></noRegion><name sortKey="Fukumi, Hideo" sort="Fukumi, Hideo" uniqKey="Fukumi H" first="Hideo" last="Fukumi">Hideo Fukumi</name><name sortKey="Kimura, Mikio" sort="Kimura, Mikio" uniqKey="Kimura M" first="Mikio" last="Kimura">Mikio Kimura</name><name sortKey="Oh, Yasumasa" sort="Oh, Yasumasa" uniqKey="Oh Y" first="Yasumasa" last="Oh">Yasumasa Oh</name><name sortKey="Ohta, Kazuyo" sort="Ohta, Kazuyo" uniqKey="Ohta K" first="Kazuyo" last="Ohta">Kazuyo Ohta</name><name sortKey="Shimojima, Rumi" sort="Shimojima, Rumi" uniqKey="Shimojima R" first="Rumi" last="Shimojima">Rumi Shimojima</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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